Cargando…
A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials
Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to promote angiogenesis, some ions released from biomaterials can also contribute to angiogenic events....
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435366/ https://www.ncbi.nlm.nih.gov/pubmed/28560015 http://dx.doi.org/10.1177/2041731417707339 |
_version_ | 1783237225058664448 |
---|---|
author | Dashnyam, Khandmaa El-Fiqi, Ahmed Buitrago, Jennifer O Perez, Roman A Knowles, Jonathan C Kim, Hae-Won |
author_facet | Dashnyam, Khandmaa El-Fiqi, Ahmed Buitrago, Jennifer O Perez, Roman A Knowles, Jonathan C Kim, Hae-Won |
author_sort | Dashnyam, Khandmaa |
collection | PubMed |
description | Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to promote angiogenesis, some ions released from biomaterials can also contribute to angiogenic events. Many silica-based biomaterials have been widely used for the repair and regeneration of tissues, mainly hard tissues such as bone and tooth structure. They have shown excellent performance in bone formation by stimulating angiogenesis. The release of silicate and others (Co and Cu ions) has therefore been implicated to play critical roles in the angiogenesis process. In this short review, we highlight the in vitro and in vivo findings of angiogenesis (and the related bone formation) stimulated by the various types of silicon-containing biomaterials where silicate ions released might play essential roles. We discuss further the possible molecular mechanisms underlying in the ion-induced angiogenic events. |
format | Online Article Text |
id | pubmed-5435366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54353662017-05-30 A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials Dashnyam, Khandmaa El-Fiqi, Ahmed Buitrago, Jennifer O Perez, Roman A Knowles, Jonathan C Kim, Hae-Won J Tissue Eng Review Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to promote angiogenesis, some ions released from biomaterials can also contribute to angiogenic events. Many silica-based biomaterials have been widely used for the repair and regeneration of tissues, mainly hard tissues such as bone and tooth structure. They have shown excellent performance in bone formation by stimulating angiogenesis. The release of silicate and others (Co and Cu ions) has therefore been implicated to play critical roles in the angiogenesis process. In this short review, we highlight the in vitro and in vivo findings of angiogenesis (and the related bone formation) stimulated by the various types of silicon-containing biomaterials where silicate ions released might play essential roles. We discuss further the possible molecular mechanisms underlying in the ion-induced angiogenic events. SAGE Publications 2017-05-15 /pmc/articles/PMC5435366/ /pubmed/28560015 http://dx.doi.org/10.1177/2041731417707339 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Review Dashnyam, Khandmaa El-Fiqi, Ahmed Buitrago, Jennifer O Perez, Roman A Knowles, Jonathan C Kim, Hae-Won A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
title | A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
title_full | A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
title_fullStr | A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
title_full_unstemmed | A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
title_short | A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
title_sort | mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435366/ https://www.ncbi.nlm.nih.gov/pubmed/28560015 http://dx.doi.org/10.1177/2041731417707339 |
work_keys_str_mv | AT dashnyamkhandmaa aminireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT elfiqiahmed aminireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT buitragojennifero aminireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT perezromana aminireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT knowlesjonathanc aminireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT kimhaewon aminireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT dashnyamkhandmaa minireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT elfiqiahmed minireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT buitragojennifero minireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT perezromana minireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT knowlesjonathanc minireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials AT kimhaewon minireviewfocusedontheproangiogenicroleofsilicateionsreleasedfromsiliconcontainingbiomaterials |