1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus

[Image: see text] Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3–8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of s...

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Autores principales: Fu, Peng, La, Scott, MacMillan, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435457/
https://www.ncbi.nlm.nih.gov/pubmed/26489038
http://dx.doi.org/10.1021/acs.jnatprod.5b00604
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author Fu, Peng
La, Scott
MacMillan, John B.
author_facet Fu, Peng
La, Scott
MacMillan, John B.
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collection PubMed
description [Image: see text] Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3–8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ-lactam moiety and a 1,3-oxazin-6-one system.
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spelling pubmed-54354572017-05-18 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus Fu, Peng La, Scott MacMillan, John B. J Nat Prod [Image: see text] Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3–8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ-lactam moiety and a 1,3-oxazin-6-one system. American Chemical Society and American Society of Pharmacognosy 2015-10-21 2016-03-25 /pmc/articles/PMC5435457/ /pubmed/26489038 http://dx.doi.org/10.1021/acs.jnatprod.5b00604 Text en Copyright © 2015 American Chemical Society and American Society of Pharmacognosy This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Fu, Peng
La, Scott
MacMillan, John B.
1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
title 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
title_full 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
title_fullStr 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
title_full_unstemmed 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
title_short 1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
title_sort 1,3-oxazin-6-one derivatives and bohemamine-type pyrrolizidine alkaloids from a marine-derived streptomyces spinoverrucosus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435457/
https://www.ncbi.nlm.nih.gov/pubmed/26489038
http://dx.doi.org/10.1021/acs.jnatprod.5b00604
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