In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment

We provide in this paper a detailed characterization of the human peripheral CD4(+) CD127(low)CD25(+) regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of the IL-6 receptor (IL-6R). We provide a description of the phenotype of this p...

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Detalles Bibliográficos
Autores principales: Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435581/
https://www.ncbi.nlm.nih.gov/pubmed/28567438
http://dx.doi.org/10.1016/j.dib.2017.04.043
Descripción
Sumario:We provide in this paper a detailed characterization of the human peripheral CD4(+) CD127(low)CD25(+) regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of the IL-6 receptor (IL-6R). We provide a description of the phenotype of this population by assessing both the surface expression by flow cytometry as well as their transcriptional profile and functional features. In addition, we also present functional data describing the responsiveness of these subsets to IL-6 signalling in vitro and to IL-2 in vivo. The data presented in this paper support the research article “Human IL-6R(hi)TIGIT(−) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile” (Ferreira RC et al., 2017; doi: 10.1016/j.clim.2017.03.002) [1].

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