Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action

Aberrant regulation of the insulin-like growth factor (IGF)/insulin (IIS)-PI3K-AKT-TOR signaling pathway is linked to major human diseases, and key components of this pathway are targets for therapeutic intervention. Current assays are molecular target- or cell culture-based platforms. Due to the gr...

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Detalles Bibliográficos
Autores principales: Liu, Chengdong, Dai, Wei, Bai, Yan, Chi, Changfeng, Xin, Yi, He, Gen, Mai, Kangsen, Duan, Cunming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435685/
https://www.ncbi.nlm.nih.gov/pubmed/28515443
http://dx.doi.org/10.1038/s41598-017-01687-3

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