Cargando…

Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications

Comorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prada-Medina, Cesar A., Fukutani, Kiyoshi F., Pavan Kumar, Nathella, Gil-Santana, Leonardo, Babu, Subash, Lichtenstein, Flávio, West, Kim, Sivakumar, Shanmugam, Menon, Pradeep A., Viswanathan, Vijay, Andrade, Bruno B., Nakaya, Helder I., Kornfeld, Hardy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435727/ https://www.ncbi.nlm.nih.gov/pubmed/28515464 http://dx.doi.org/10.1038/s41598-017-01767-4

Ejemplares similares

Heightened circulating levels of antimicrobial peptides in tuberculosis—Diabetes co-morbidity and reversal upon treatment
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis – Diabetes co-morbidity
por: Kumar, Nathella Pavan, et al.
Publicado: (2021)

Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
por: Kumar, Nathella Pavan, et al.
Publicado: (2019)

Elevated levels of matrix metalloproteinases reflect severity and extent of disease in tuberculosis-diabetes co-morbidity and are predominantly reversed following standard anti-tuberculosis or metformin treatment
por: Kumar, Nathella P., et al.
Publicado: (2018)

Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden
por: Pavan Kumar, Nathella, et al.
Publicado: (2019)

Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy
por: Kumar, Nathella Pavan, et al.
Publicado: (2019)

Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
por: Kumar, Nathella Pavan, et al.
Publicado: (2021)

Chitinase and indoleamine 2, 3-dioxygenase are prognostic biomarkers for unfavorable treatment outcomes in pulmonary tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2023)

Plasma chemokines are biomarkers of disease severity, higher bacterial burden and delayed sputum culture conversion in pulmonary tuberculosis
por: Kumar, Nathella P., et al.
Publicado: (2019)

Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis
por: Kumar, Nathella P., et al.
Publicado: (2020)

High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity
por: Kathamuthu, Gokul Raj, et al.
Publicado: (2022)

Decreased Frequencies of Gamma/Delta T Cells Expressing Th1/Th17 Cytokine, Cytotoxic, and Immune Markers in Latent Tuberculosis-Diabetes/Pre-Diabetes Comorbidity
por: Kathamuthu, Gokul Raj, et al.
Publicado: (2021)

A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
por: Queiroz, Artur T. L., et al.
Publicado: (2023)

Coincident Pre-Diabetes Is Associated with Dysregulated Cytokine Responses in Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2014)

Impact of diabetes mellitus on immunity to latent tuberculosis infection
por: Kumar, Nathella Pavan, et al.
Publicado: (2023)

Multi-Dimensionality Immunophenotyping Analyses of MAIT Cells Expressing Th1/Th17 Cytokines and Cytotoxic Markers in Latent Tuberculosis Diabetes Comorbidity
por: Kathamuthu, Gokul Raj, et al.
Publicado: (2022)

Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
por: Oliveira-de-Souza, Deivide, et al.
Publicado: (2020)

Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2023)

Circulating Angiogenic Factors as Biomarkers of Disease Severity and Bacterial Burden in Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2016)

Diminished plasma levels of common γ-chain cytokines in pulmonary tuberculosis and reversal following treatment
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and Th17/Tc17 responses in latent Mycobacterium tuberculosis infection
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection
por: Cheekatla, Satyanarayana Swamy, et al.
Publicado: (2016)

Helminth Mediated Attenuation of Systemic Inflammation and Microbial Translocation in Helminth-Diabetes Comorbidity
por: Rajamanickam, Anuradha, et al.
Publicado: (2020)

Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations
por: Oliveira-de-Souza, Deivide, et al.
Publicado: (2019)

Altered systemic levels of acute phase proteins in tuberculous lymphadenitis and modulation after treatment
por: Kathamuthu, Gokul Raj, et al.
Publicado: (2020)

Augmented Innate and Adaptive Immune Responses Under Conditions of Diabetes–Filariasis Comorbidity
por: Sibi, Joy Manohar, et al.
Publicado: (2021)

Evidence of Microbial Translocation Associated with Perturbations in T Cell and Antigen-Presenting Cell Homeostasis in Hookworm Infections
por: George, Palakkal Jovvian, et al.
Publicado: (2012)

Role of myeloid derived suppressor cells in tuberculosis infection and disease
por: Kumar, Nathella Pavan, et al.
Publicado: (2014)

Decreased Frequencies of Circulating CD4(+) T Follicular Helper Cells Associated with Diminished Plasma IL-21 in Active Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2014)

Expansion of Pathogen-Specific Mono- and Multifunctional Th1 and Th17 Cells in Multi-Focal Tuberculous Lymphadenitis
por: Kumar, Nathella Pavan, et al.
Publicado: (2013)

Immunology of oral candidiasis
por: Dineshshankar, Janardhanam, et al.
Publicado: (2014)

Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study
por: Gupte, Akshay N., et al.
Publicado: (2022)

Helminth Infections Coincident with Active Pulmonary Tuberculosis Inhibit Mono- and Multifunctional CD4(+) and CD8(+) T Cell Responses in a Process Dependent on IL-10
por: George, Parakkal Jovvian, et al.
Publicado: (2014)

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Are Potential Biomarkers of Pulmonary and Extra-Pulmonary Tuberculosis
por: Kathamuthu, Gokul Raj, et al.
Publicado: (2020)

The recent trend in mycobacterial strain diversity among extra pulmonary lymph node tuberculosis and their association with drug resistance and the host immunological response in South India
por: Sivakumar, Shanmugam, et al.
Publicado: (2020)

IL-10 Dependent Suppression of Type 1, Type 2 and Type 17 Cytokines in Active Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2013)

Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India.
por: Venkataraman, Aishwarya, et al.
Publicado: (2021)

Effect of BCG vaccination on proinflammatory responses in elderly individuals
por: Pavan Kumar, Nathella, et al.
Publicado: (2021)

Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children
por: Kumar, Nathella Pavan, et al.
Publicado: (2021)

Coincident Helminth Infection Modulates Systemic Inflammation and Immune Activation in Active Pulmonary Tuberculosis
por: George, Parakkal Jovvian, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_kvlbee81rcfial6rlg1eub5cd5