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Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival

The sensory hair cells of the inner ear are exquisitely sensitive to ototoxic insults. Loss of hair cells after exposure to ototoxic agents causes hearing loss. Chemotherapeutic agents such as cisplatin causes hair cell loss. Cisplatin forms DNA mono-adducts as well as intra- and inter-strand DNA cr...

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Detalles Bibliográficos
Autores principales:	Jadali, Azadeh, Ying, Yu-Lan M., Kwan, Kelvin Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435747/ https://www.ncbi.nlm.nih.gov/pubmed/28572758 http://dx.doi.org/10.3389/fncel.2017.00137

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