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Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints

BACKGROUND: Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive...

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Autores principales: Buiar, Pedro Grachinski, de Azevedo, Sérgio Jobim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435810/
https://www.ncbi.nlm.nih.gov/pubmed/28573105
http://dx.doi.org/10.3389/fonc.2017.00099
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author Buiar, Pedro Grachinski
de Azevedo, Sérgio Jobim
author_facet Buiar, Pedro Grachinski
de Azevedo, Sérgio Jobim
author_sort Buiar, Pedro Grachinski
collection PubMed
description BACKGROUND: Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive disease in its metastatic scenario, and the new armament like targeted and immunotherapies are still looking for more robust evidence. CASE PRESENTATION: We report a rare case of uveal melanoma in a patient younger than 20 years, with abdominal pain as his initial complaint. He did not present the typical visual symptoms of the primary site because of an auto accident suffered 4 months before the presentation, letting him blind of the eye affected by the tumor development. CONCLUSION: There is always a possibility of the diagnosis of uveal melanoma in cases with associated isolated hepatic metastases, even in a young population, where this hypothesis is often rejected by the epidemiological frequency of other tumors. This rare case is a useful example.
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spelling pubmed-54358102017-06-01 Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints Buiar, Pedro Grachinski de Azevedo, Sérgio Jobim Front Oncol Oncology BACKGROUND: Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive disease in its metastatic scenario, and the new armament like targeted and immunotherapies are still looking for more robust evidence. CASE PRESENTATION: We report a rare case of uveal melanoma in a patient younger than 20 years, with abdominal pain as his initial complaint. He did not present the typical visual symptoms of the primary site because of an auto accident suffered 4 months before the presentation, letting him blind of the eye affected by the tumor development. CONCLUSION: There is always a possibility of the diagnosis of uveal melanoma in cases with associated isolated hepatic metastases, even in a young population, where this hypothesis is often rejected by the epidemiological frequency of other tumors. This rare case is a useful example. Frontiers Media S.A. 2017-05-18 /pmc/articles/PMC5435810/ /pubmed/28573105 http://dx.doi.org/10.3389/fonc.2017.00099 Text en Copyright © 2017 Buiar and Azevedo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Buiar, Pedro Grachinski
de Azevedo, Sérgio Jobim
Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
title Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
title_full Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
title_fullStr Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
title_full_unstemmed Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
title_short Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
title_sort atypical presentation: metastatic uveal melanoma in a young patient without visual complaints
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435810/
https://www.ncbi.nlm.nih.gov/pubmed/28573105
http://dx.doi.org/10.3389/fonc.2017.00099
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