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Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints
BACKGROUND: Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435810/ https://www.ncbi.nlm.nih.gov/pubmed/28573105 http://dx.doi.org/10.3389/fonc.2017.00099 |
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author | Buiar, Pedro Grachinski de Azevedo, Sérgio Jobim |
author_facet | Buiar, Pedro Grachinski de Azevedo, Sérgio Jobim |
author_sort | Buiar, Pedro Grachinski |
collection | PubMed |
description | BACKGROUND: Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive disease in its metastatic scenario, and the new armament like targeted and immunotherapies are still looking for more robust evidence. CASE PRESENTATION: We report a rare case of uveal melanoma in a patient younger than 20 years, with abdominal pain as his initial complaint. He did not present the typical visual symptoms of the primary site because of an auto accident suffered 4 months before the presentation, letting him blind of the eye affected by the tumor development. CONCLUSION: There is always a possibility of the diagnosis of uveal melanoma in cases with associated isolated hepatic metastases, even in a young population, where this hypothesis is often rejected by the epidemiological frequency of other tumors. This rare case is a useful example. |
format | Online Article Text |
id | pubmed-5435810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54358102017-06-01 Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints Buiar, Pedro Grachinski de Azevedo, Sérgio Jobim Front Oncol Oncology BACKGROUND: Uveal melanoma is a rare and aggressive subtype of melanoma, with singular characteristics that separate it from the most famous cutaneous melanoma. This uncommon condition becomes even rarer if we look at young population. Common chemotherapy regimens does not work with this aggressive disease in its metastatic scenario, and the new armament like targeted and immunotherapies are still looking for more robust evidence. CASE PRESENTATION: We report a rare case of uveal melanoma in a patient younger than 20 years, with abdominal pain as his initial complaint. He did not present the typical visual symptoms of the primary site because of an auto accident suffered 4 months before the presentation, letting him blind of the eye affected by the tumor development. CONCLUSION: There is always a possibility of the diagnosis of uveal melanoma in cases with associated isolated hepatic metastases, even in a young population, where this hypothesis is often rejected by the epidemiological frequency of other tumors. This rare case is a useful example. Frontiers Media S.A. 2017-05-18 /pmc/articles/PMC5435810/ /pubmed/28573105 http://dx.doi.org/10.3389/fonc.2017.00099 Text en Copyright © 2017 Buiar and Azevedo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Buiar, Pedro Grachinski de Azevedo, Sérgio Jobim Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints |
title | Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints |
title_full | Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints |
title_fullStr | Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints |
title_full_unstemmed | Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints |
title_short | Atypical Presentation: Metastatic Uveal Melanoma in a Young Patient without Visual Complaints |
title_sort | atypical presentation: metastatic uveal melanoma in a young patient without visual complaints |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435810/ https://www.ncbi.nlm.nih.gov/pubmed/28573105 http://dx.doi.org/10.3389/fonc.2017.00099 |
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