Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease

Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies,...

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Detalles Bibliográficos
Autores principales: Si, Xiaoli, Pu, Jiali, Zhang, Baorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Movement Disorder Society 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435834/
https://www.ncbi.nlm.nih.gov/pubmed/28479587
http://dx.doi.org/10.14802/jmd.16061
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author Si, Xiaoli
Pu, Jiali
Zhang, Baorong
author_facet Si, Xiaoli
Pu, Jiali
Zhang, Baorong
author_sort Si, Xiaoli
collection PubMed
description Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy.
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spelling pubmed-54358342017-05-30 Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease Si, Xiaoli Pu, Jiali Zhang, Baorong J Mov Disord Review Article Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease, is characterized by the loss of nigral dopaminergic neurons. PD leads to a series of clinical symptoms, including motor and non-motor disturbances. α-synuclein, the major component of Lewy bodies, is a hallmark lesion in PD. In this review, we concentrate on presenting the latest research on the structure, distribution, and function of α-synuclein, and its interactions with PD. We also summarize the clinic applications of α-synuclein, which suggest its use as a biomarker, and the latest progress in α-synuclein therapy. The Korean Movement Disorder Society 2017-05 2017-05-08 /pmc/articles/PMC5435834/ /pubmed/28479587 http://dx.doi.org/10.14802/jmd.16061 Text en Copyright © 2017 The Korean Movement Disorder Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Si, Xiaoli
Pu, Jiali
Zhang, Baorong
Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
title Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
title_full Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
title_fullStr Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
title_full_unstemmed Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
title_short Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease
title_sort structure, distribution, and genetic profile of α-synuclein and their potential clinical application in parkinson’s disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435834/
https://www.ncbi.nlm.nih.gov/pubmed/28479587
http://dx.doi.org/10.14802/jmd.16061
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