Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimod...

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Detalles Bibliográficos
Autores principales: Picardi, Ernesto, Horner, David S., Pesole, Graziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435858/
https://www.ncbi.nlm.nih.gov/pubmed/28258159
http://dx.doi.org/10.1261/rna.058271.116
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author Picardi, Ernesto
Horner, David S.
Pesole, Graziano
author_facet Picardi, Ernesto
Horner, David S.
Pesole, Graziano
author_sort Picardi, Ernesto
collection PubMed
description While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
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spelling pubmed-54358582017-06-02 Single-cell transcriptomics reveals specific RNA editing signatures in the human brain Picardi, Ernesto Horner, David S. Pesole, Graziano RNA Report While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics. Cold Spring Harbor Laboratory Press 2017-06 /pmc/articles/PMC5435858/ /pubmed/28258159 http://dx.doi.org/10.1261/rna.058271.116 Text en © 2017 Picardi et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by/4.0/ This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Report
Picardi, Ernesto
Horner, David S.
Pesole, Graziano
Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
title Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
title_full Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
title_fullStr Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
title_full_unstemmed Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
title_short Single-cell transcriptomics reveals specific RNA editing signatures in the human brain
title_sort single-cell transcriptomics reveals specific rna editing signatures in the human brain
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435858/
https://www.ncbi.nlm.nih.gov/pubmed/28258159
http://dx.doi.org/10.1261/rna.058271.116
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