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High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon

CRISPR-Cas systems allow bacteria and archaea to acquire sequence-specific immunity against selfish genetic elements such as viruses and plasmids, by specific degradation of invader DNA or RNA. However, this involves the risk of autoimmunity if immune memory against host DNA is mistakenly acquired....

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Detalles Bibliográficos
Autores principales:	Stachler, Aris-Edda, Turgeman-Grott, Israela, Shtifman-Segal, Ella, Allers, Thorsten, Marchfelder, Anita, Gophna, Uri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435918/ https://www.ncbi.nlm.nih.gov/pubmed/28334774 http://dx.doi.org/10.1093/nar/gkx150

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