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NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate

APOBEC3 proteins are double-edged swords. They deaminate cytosine to uracil in single-stranded DNA and provide protection, as part of our innate immune system, against viruses and retrotransposons, but they are also involved in cancer evolution and development of drug resistance. We report a solutio...

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Detalles Bibliográficos
Autores principales:	Harjes, Stefan, Jameson, Geoffrey B., Filichev, Vyacheslav V., Edwards, Patrick J. B., Harjes, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435981/ https://www.ncbi.nlm.nih.gov/pubmed/28369637 http://dx.doi.org/10.1093/nar/gkx196

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