Visualising the membrane viscosity of porcine eye lens cells using molecular rotors

The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive ‘molecular rotors’ to map the microscopic viscosity within...

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Autores principales: Sherin, Peter S., López-Duarte, Ismael, Dent, Michael R., Kubánková, Markéta, Vyšniauskas, Aurimas, Bull, James A., Reshetnikova, Evdokiya S., Klymchenko, Andrey S., Tsentalovich, Yuri P., Kuimova, Marina K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435988/
https://www.ncbi.nlm.nih.gov/pubmed/28580097
http://dx.doi.org/10.1039/c6sc05369f
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author Sherin, Peter S.
López-Duarte, Ismael
Dent, Michael R.
Kubánková, Markéta
Vyšniauskas, Aurimas
Bull, James A.
Reshetnikova, Evdokiya S.
Klymchenko, Andrey S.
Tsentalovich, Yuri P.
Kuimova, Marina K.
author_facet Sherin, Peter S.
López-Duarte, Ismael
Dent, Michael R.
Kubánková, Markéta
Vyšniauskas, Aurimas
Bull, James A.
Reshetnikova, Evdokiya S.
Klymchenko, Andrey S.
Tsentalovich, Yuri P.
Kuimova, Marina K.
author_sort Sherin, Peter S.
collection PubMed
description The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive ‘molecular rotors’ to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.
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spelling pubmed-54359882017-06-02 Visualising the membrane viscosity of porcine eye lens cells using molecular rotors Sherin, Peter S. López-Duarte, Ismael Dent, Michael R. Kubánková, Markéta Vyšniauskas, Aurimas Bull, James A. Reshetnikova, Evdokiya S. Klymchenko, Andrey S. Tsentalovich, Yuri P. Kuimova, Marina K. Chem Sci Chemistry The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive ‘molecular rotors’ to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation. Royal Society of Chemistry 2017-05-01 2017-02-14 /pmc/articles/PMC5435988/ /pubmed/28580097 http://dx.doi.org/10.1039/c6sc05369f Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Sherin, Peter S.
López-Duarte, Ismael
Dent, Michael R.
Kubánková, Markéta
Vyšniauskas, Aurimas
Bull, James A.
Reshetnikova, Evdokiya S.
Klymchenko, Andrey S.
Tsentalovich, Yuri P.
Kuimova, Marina K.
Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
title Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
title_full Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
title_fullStr Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
title_full_unstemmed Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
title_short Visualising the membrane viscosity of porcine eye lens cells using molecular rotors
title_sort visualising the membrane viscosity of porcine eye lens cells using molecular rotors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435988/
https://www.ncbi.nlm.nih.gov/pubmed/28580097
http://dx.doi.org/10.1039/c6sc05369f
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