Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature

Pazopanib, a multitargeting tyrosine kinase inhibitor, has single-agent activity in patients with advanced soft-tissue sarcoma. Herein, we describe 2 cases of pneumothorax that occurred during pazopanib treatment in patients with soft-tissue sarcoma. These 2 patients had multiple lung metastases. Ac...

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Autores principales: Nakahara, Yoshiro, Fukui, Tomoya, Katono, Ken, Nishizawa, Yuuki, Okuma, Yusuke, Ikegami, Masachika, Sasaki, Jiichiro, Masuda, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436012/
https://www.ncbi.nlm.nih.gov/pubmed/28559816
http://dx.doi.org/10.1159/000463380
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author Nakahara, Yoshiro
Fukui, Tomoya
Katono, Ken
Nishizawa, Yuuki
Okuma, Yusuke
Ikegami, Masachika
Sasaki, Jiichiro
Masuda, Noriyuki
author_facet Nakahara, Yoshiro
Fukui, Tomoya
Katono, Ken
Nishizawa, Yuuki
Okuma, Yusuke
Ikegami, Masachika
Sasaki, Jiichiro
Masuda, Noriyuki
author_sort Nakahara, Yoshiro
collection PubMed
description Pazopanib, a multitargeting tyrosine kinase inhibitor, has single-agent activity in patients with advanced soft-tissue sarcoma. Herein, we describe 2 cases of pneumothorax that occurred during pazopanib treatment in patients with soft-tissue sarcoma. These 2 patients had multiple lung metastases. According to previous reports and our past experience, the risk of pneumothorax may be higher in patients with multiple lung metastases. Although a causal relationship is uncertain, the risk of pneumothorax when prescribing pazopanib for these patients should be considered.
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spelling pubmed-54360122017-05-30 Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature Nakahara, Yoshiro Fukui, Tomoya Katono, Ken Nishizawa, Yuuki Okuma, Yusuke Ikegami, Masachika Sasaki, Jiichiro Masuda, Noriyuki Case Rep Oncol Case Report Pazopanib, a multitargeting tyrosine kinase inhibitor, has single-agent activity in patients with advanced soft-tissue sarcoma. Herein, we describe 2 cases of pneumothorax that occurred during pazopanib treatment in patients with soft-tissue sarcoma. These 2 patients had multiple lung metastases. According to previous reports and our past experience, the risk of pneumothorax may be higher in patients with multiple lung metastases. Although a causal relationship is uncertain, the risk of pneumothorax when prescribing pazopanib for these patients should be considered. S. Karger AG 2017-04-18 /pmc/articles/PMC5436012/ /pubmed/28559816 http://dx.doi.org/10.1159/000463380 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Nakahara, Yoshiro
Fukui, Tomoya
Katono, Ken
Nishizawa, Yuuki
Okuma, Yusuke
Ikegami, Masachika
Sasaki, Jiichiro
Masuda, Noriyuki
Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature
title Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature
title_full Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature
title_fullStr Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature
title_full_unstemmed Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature
title_short Pneumothorax during Pazopanib Treatment in Patients with Soft-Tissue Sarcoma: Two Case Reports and a Review of the Literature
title_sort pneumothorax during pazopanib treatment in patients with soft-tissue sarcoma: two case reports and a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436012/
https://www.ncbi.nlm.nih.gov/pubmed/28559816
http://dx.doi.org/10.1159/000463380
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