TNFα drives mitochondrial stress in POMC neurons in obesity

Consuming a calorically dense diet stimulates microglial reactivity in the mediobasal hypothalamus (MBH) in association with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reduction in POMC neuronal function is secondary to the microglial activation is unclear....

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Detalles Bibliográficos
Autores principales: Yi, Chun-Xia, Walter, Marc, Gao, Yuanqing, Pitra, Soledad, Legutko, Beata, Kälin, Stefanie, Layritz, Clarita, García-Cáceres, Cristina, Bielohuby, Maximilian, Bidlingmaier, Martin, Woods, Stephen C., Ghanem, Alexander, Conzelmann, Karl-Klaus, Stern, Javier E., Jastroch, Martin, Tschöp, Matthias H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436136/
https://www.ncbi.nlm.nih.gov/pubmed/28489068
http://dx.doi.org/10.1038/ncomms15143

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