Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

Interactions with the immune system may lead tumorigenic cells into dormancy. However, the underlying molecular mechanism is poorly understood. Using a 3D fibrin gel model, we show that IFN-γ induces tumour-repopulating cells (TRCs) to enter dormancy through an indolamine 2,3-dioxygenase 1 (IDO1)-ky...

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Detalles Bibliográficos
Autores principales: Liu, Yuying, Liang, Xiaoyu, Yin, Xiaonan, Lv, Jiadi, Tang, Ke, Ma, Jingwei, Ji, Tiantian, Zhang, Huafeng, Dong, Wenqian, Jin, Xun, Chen, Degao, Li, Yanchun, Zhang, Songyan, Xie, Heidi Q., Zhao, Bin, Zhao, Tong, Lu, Jinzhi, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F. Xiao-Feng, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436221/
https://www.ncbi.nlm.nih.gov/pubmed/28488695
http://dx.doi.org/10.1038/ncomms15207

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