Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. Ras activation in cancer cells drives protein internalization via macropinocytosis as a key nutrient-gaining process. By utilizing this...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jia-Lin, Jiang, Gan, Song, Qing-Xiang, Gu, Xiao, Hu, Meng, Wang, Xiao-Lin, Song, Hua-Hua, Chen, Le-Pei, Lin, Ying-Ying, Jiang, Di, Chen, Jun, Feng, Jun-Feng, Qiu, Yong-Ming, Jiang, Ji-Yao, Jiang, Xin-Guo, Chen, Hong-Zhuan, Gao, Xiao-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436231/
https://www.ncbi.nlm.nih.gov/pubmed/28489075
http://dx.doi.org/10.1038/ncomms15144

Ejemplares similares

Ejemplares similares