Initial Clinical Experience with (68)Ga-DOTA-NOC Prepared Using (68)Ga from Nanoceria-polyacrylonitrile Composite Sorbent-based (68)Ge/(68)Ga Generator and Freeze-dried DOTA-NOC Kits

Somatostatin receptor positron emission tomography–computed tomography (PET/CT) with (68)Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized ther...

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Detalles Bibliográficos
Autores principales: Chandra, Piyush, Shetye, Bhakti, Chakravarty, Rubel, Mukherjee, Archana, Pandey, Usha, Jha, Ashish Kumar, Purandare, Nilendu, Shah, Sneha, Agrawal, Archi, Ram, Ramu, Dash, Ashutosh, Rangarajan, Venkatesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436320/
https://www.ncbi.nlm.nih.gov/pubmed/28553181
http://dx.doi.org/10.4103/1450-1147.203072
Descripción
Sumario:Somatostatin receptor positron emission tomography–computed tomography (PET/CT) with (68)Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized therapy with peptide receptor-based radionuclide therapy. With growing utilization of PET/CT in developing countries, availability of the indigenous GMP-certified (68)Ge/(68)Ga generators is expected to further promote cost-effective molecular imaging service to the cancer patients. We present our initial clinical experience in 32 patients injected with (68)Ga-DOTA-NOC prepared using (68)Ga eluted from Bhabha Atomic Research Centre nanoceria-polyacrylonitrile sorbent-based (68)Ge/(68)Ga generator and freeze-dried DOTA-NOC cold kits.

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