Cargando…

The complexities underlying age-related macular degeneration: could amyloid beta play an important role?

Age-related macular degeneration (AMD) causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to occur in the retina for many years before AMD manifests from midlife onwards to affect a large proportion of the elderly. Although genetic as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lynn, Savannah A., Keeling, Eloise, Munday, Rosie, Gabha, Gagandeep, Griffiths, Helen, Lotery, Andrew J., Ratnayaka, J. Arjuna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2017
Materias:	Invited Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436342/ https://www.ncbi.nlm.nih.gov/pubmed/28553324 http://dx.doi.org/10.4103/1673-5374.205083

Ejemplares similares

The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)
por: Taylor-Walker, George, et al.
Publicado: (2016)

Dementia of the eye: the role of amyloid beta in retinal degeneration
por: Ratnayaka, J A, et al.
Publicado: (2015)

Challenges in studying geographic atrophy (GA) age-related macular degeneration: the potential of a new mouse model with GA-like features
por: Ratnayaka, J. Arjuna, et al.
Publicado: (2019)

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
por: Keeling, Eloise, et al.
Publicado: (2018)

Serial block face scanning electron microscopy reveals novel organizational details of the retinal pigment epithelium
por: Ratnayaka, J. Arjuna, et al.
Publicado: (2021)

Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina
por: Miller, Rebecca D., et al.
Publicado: (2023)

A High Fat “Western‐style” Diet Induces AMD‐Like Features in Wildtype Mice
por: Keeling, Eloise, et al.
Publicado: (2022)

Oligomeric Aβ(1-42) Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function
por: Lynn, Savannah A., et al.
Publicado: (2021)

A convenient protocol for establishing a human cell culture model of the outer retina.
por: Lynn, Savannah A., et al.
Publicado: (2018)

Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism
por: Sanchez-Bretano, Aida, et al.
Publicado: (2023)

A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy
por: Khan, Adnan H., et al.
Publicado: (2023)

A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy
por: Ibbett, Paul, et al.
Publicado: (2019)

An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy
por: Keeling, Eloise, et al.
Publicado: (2020)

Risk factors for progression of age‐related macular degeneration
por: Heesterbeek, Thomas J, et al.
Publicado: (2020)

The disparity between funding for eye research vs. the high cost of sight-loss in the UK
por: Dewing, Jennifer M., et al.
Publicado: (2022)

3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina
por: Keeling, Eloise, et al.
Publicado: (2020)

Chlamydia infection status, genotype, and age-related macular degeneration
por: Khandhadia, Sam, et al.
Publicado: (2012)

Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE
por: Lynn, Savannah A., et al.
Publicado: (2017)

Epigenetics in age-related macular degeneration: new discoveries and future perspectives
por: Gemenetzi, M., et al.
Publicado: (2020)

The Diverse Roles of TIMP-3: Insights into Degenerative Diseases of the Senescent Retina and Brain
por: Dewing, Jennifer M., et al.
Publicado: (2019)

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration
por: Zhang, Jian-Nan, et al.
Publicado: (2017)

Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons
por: Biasetti, Luca, et al.
Publicado: (2022)

Gene, Cell and Antibody-Based Therapies for the Treatment of Age-Related Macular Degeneration
por: Akyol, Engin, et al.
Publicado: (2020)

Complement factor I and age-related macular degeneration
por: Alexander, Philip, et al.
Publicado: (2014)

Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
por: Warwick, Alasdair, et al.
Publicado: (2014)

Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention
por: Marsh, Jade, et al.
Publicado: (2018)

Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort
por: Kaye, Rebecca A., et al.
Publicado: (2021)

Epigenetic Age Acceleration Is Not Associated with Age-Related Macular Degeneration
por: Saptarshi, Neil, et al.
Publicado: (2021)

Y chromosome mosaicism is associated with age-related macular degeneration
por: Grassmann, Felix, et al.
Publicado: (2018)

Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank
por: Tzoumas, Nikolaos, et al.
Publicado: (2022)

Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
por: Wang, Minwei, et al.
Publicado: (2021)

Socioeconomic risk factors and age-related macular degeneration in the UK Biobank study
por: Yip, Jennifer Lai Yee, et al.
Publicado: (2021)

Developmental onset of cardiovascular disease—Could the proof be in the placenta?
por: D'Errico, Jeanine N., et al.
Publicado: (2019)

Treatment of Appendicitis Could Become Even Less Invasive
por: Fonnes, Siv
Publicado: (2023)

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment
por: Khan, Adnan H., et al.
Publicado: (2023)

Odorants could elicit repair processes in melanized neuronal and skin cells
por: Pavan, Barbara, et al.
Publicado: (2017)

Retinoic Acid Receptor Beta in Pathophysiology of Age-Related Macular Degeneration
por: TAVAKOLIFAR, Saeed, et al.
Publicado: (2015)

Reading in the presence of macular disease: a mini‐review
por: Chung, Susana T L
Publicado: (2020)

Beta-catenin in disease
por: Prakash, Sharada, et al.
Publicado: (2016)

Amyloid in the ageing brain: New frameworks and perspectives
por: Hunter, Sally, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u6amj50ekjjof8pfncm7c31ehf