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Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy

With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to...

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Autores principales: Li, Hong-xin, Feng, Xing, Wang, Qian, Dong, Xuan, Yu, Min, Tu, Wen-juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436359/
https://www.ncbi.nlm.nih.gov/pubmed/28553341
http://dx.doi.org/10.4103/1673-5374.205102
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author Li, Hong-xin
Feng, Xing
Wang, Qian
Dong, Xuan
Yu, Min
Tu, Wen-juan
author_facet Li, Hong-xin
Feng, Xing
Wang, Qian
Dong, Xuan
Yu, Min
Tu, Wen-juan
author_sort Li, Hong-xin
collection PubMed
description With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy (14 moderate cases and 8 severe cases) underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy.
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spelling pubmed-54363592017-05-26 Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy Li, Hong-xin Feng, Xing Wang, Qian Dong, Xuan Yu, Min Tu, Wen-juan Neural Regen Res Research Article With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy (14 moderate cases and 8 severe cases) underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy. Medknow Publications & Media Pvt Ltd 2017-04 /pmc/articles/PMC5436359/ /pubmed/28553341 http://dx.doi.org/10.4103/1673-5374.205102 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Li, Hong-xin
Feng, Xing
Wang, Qian
Dong, Xuan
Yu, Min
Tu, Wen-juan
Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
title Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
title_full Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
title_fullStr Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
title_full_unstemmed Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
title_short Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
title_sort diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436359/
https://www.ncbi.nlm.nih.gov/pubmed/28553341
http://dx.doi.org/10.4103/1673-5374.205102
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