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Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring

Chronic psychological stress is a risk factor for osteoporosis. Maternal active mastication during prenatal stress attenuates stress response. The aim of this study is to test the hypothesis that maternal active mastication influences the effect of prenatal stress on bone mass and bone microstructur...

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Autores principales: Azuma, Kagaku, Ogura, Minori, Kondo, Hiroko, Suzuki, Ayumi, Hayashi, Sakurako, Iinuma, Mitsuo, Onozuka, Minoru, Kubo, Kin-ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436477/
https://www.ncbi.nlm.nih.gov/pubmed/28553167
http://dx.doi.org/10.7150/ijms.18298
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author Azuma, Kagaku
Ogura, Minori
Kondo, Hiroko
Suzuki, Ayumi
Hayashi, Sakurako
Iinuma, Mitsuo
Onozuka, Minoru
Kubo, Kin-ya
author_facet Azuma, Kagaku
Ogura, Minori
Kondo, Hiroko
Suzuki, Ayumi
Hayashi, Sakurako
Iinuma, Mitsuo
Onozuka, Minoru
Kubo, Kin-ya
author_sort Azuma, Kagaku
collection PubMed
description Chronic psychological stress is a risk factor for osteoporosis. Maternal active mastication during prenatal stress attenuates stress response. The aim of this study is to test the hypothesis that maternal active mastication influences the effect of prenatal stress on bone mass and bone microstructure in adult offspring. Pregnant ddY mice were randomly divided into control, stress, and stress/chewing groups. Mice in the stress and stress/chewing groups were placed in a ventilated restraint tube for 45 minutes, 3 times a day, and was initiated on day 12 of gestation and continued until delivery. Mice in the stress/chewing group were allowed to chew a wooden stick during the restraint stress period. The bone response of 5-month-old male offspring was evaluated using quantitative micro-CT, bone histomorphometry, and biochemical markers. Prenatal stress resulted in significant decrease of trabecular bone mass in both vertebra and distal femur of the offspring. Maternal active mastication during prenatal stress attenuated the reduced bone formation and increased bone resorption, improved the lower trabecular bone volume and bone microstructural deterioration induced by prenatal stress in the offspring. These findings indicate that maternal active mastication during prenatal stress can ameliorate prenatal stress-induced lower bone mass of the vertebra and femur in adult offspring. Active mastication during prenatal stress in dams could be an effective coping strategy to prevent lower bone mass in their offspring.
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spelling pubmed-54364772017-05-26 Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring Azuma, Kagaku Ogura, Minori Kondo, Hiroko Suzuki, Ayumi Hayashi, Sakurako Iinuma, Mitsuo Onozuka, Minoru Kubo, Kin-ya Int J Med Sci Research Paper Chronic psychological stress is a risk factor for osteoporosis. Maternal active mastication during prenatal stress attenuates stress response. The aim of this study is to test the hypothesis that maternal active mastication influences the effect of prenatal stress on bone mass and bone microstructure in adult offspring. Pregnant ddY mice were randomly divided into control, stress, and stress/chewing groups. Mice in the stress and stress/chewing groups were placed in a ventilated restraint tube for 45 minutes, 3 times a day, and was initiated on day 12 of gestation and continued until delivery. Mice in the stress/chewing group were allowed to chew a wooden stick during the restraint stress period. The bone response of 5-month-old male offspring was evaluated using quantitative micro-CT, bone histomorphometry, and biochemical markers. Prenatal stress resulted in significant decrease of trabecular bone mass in both vertebra and distal femur of the offspring. Maternal active mastication during prenatal stress attenuated the reduced bone formation and increased bone resorption, improved the lower trabecular bone volume and bone microstructural deterioration induced by prenatal stress in the offspring. These findings indicate that maternal active mastication during prenatal stress can ameliorate prenatal stress-induced lower bone mass of the vertebra and femur in adult offspring. Active mastication during prenatal stress in dams could be an effective coping strategy to prevent lower bone mass in their offspring. Ivyspring International Publisher 2017-04-06 /pmc/articles/PMC5436477/ /pubmed/28553167 http://dx.doi.org/10.7150/ijms.18298 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Azuma, Kagaku
Ogura, Minori
Kondo, Hiroko
Suzuki, Ayumi
Hayashi, Sakurako
Iinuma, Mitsuo
Onozuka, Minoru
Kubo, Kin-ya
Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring
title Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring
title_full Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring
title_fullStr Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring
title_full_unstemmed Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring
title_short Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring
title_sort maternal active mastication during prenatal stress ameliorates prenatal stress-induced lower bone mass in adult mouse offspring
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436477/
https://www.ncbi.nlm.nih.gov/pubmed/28553167
http://dx.doi.org/10.7150/ijms.18298
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