Peptide vaccination in the presence of adjuvants in patients after hematopoietic stem cell transplantation with CD4+ T cell reconstitution elicits consistent CD8+ T cell responses

Rationale: Patients receiving an allogeneic stem cell graft from cytomegalovirus (CMV) seronegative donors are particularly prone to CMV reactivation with a high risk of disease and mortality. Therefore we developed and manufactured a novel vaccine and initiated a clinical phase I trial with a CMV p...

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Detalles Bibliográficos
Autores principales: Schmitt, Michael, Schmitt, Anita, Wiesneth, Markus, Hückelhoven, Angela, Wu, Zeguang, Kuball, Jürgen, Wang, Lei, Schauwecker, Peter, Hofmann, Susanne, Götz, Marlies, Michels, Birgit, Maccari, Birgit, Wuchter, Patrick, Eckstein, Volker, Mertens, Thomas, Schnitzler, Paul, Döhner, Hartmut, Ho, Anthony D., Bunjes, Donald W., Dreger, Peter, Schrezenmeier, Hubert, Greiner, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436522/
https://www.ncbi.nlm.nih.gov/pubmed/28529646
http://dx.doi.org/10.7150/thno.18301

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