Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens

BACKGROUND: Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinat...

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Detalles Bibliográficos
Autores principales: Cento, Valeria, Nguyen, Thi Huyen Tram, Di Carlo, Domenico, Biliotti, Elisa, Gianserra, Laura, Lenci, Ilaria, Di Paolo, Daniele, Calvaruso, Vincenza, Teti, Elisabetta, Cerrone, Maddalena, Romagnoli, Dante, Melis, Michela, Danieli, Elena, Menzaghi, Barbara, Polilli, Ennio, Siciliano, Massimo, Nicolini, Laura Ambra, Di Biagio, Antonio, Magni, Carlo Federico, Bolis, Matteo, Antonucci, Francesco Paolo, Di Maio, Velia Chiara, Alfieri, Roberta, Sarmati, Loredana, Casalino, Paolo, Bernardini, Sergio, Micheli, Valeria, Rizzardini, Giuliano, Parruti, Giustino, Quirino, Tiziana, Puoti, Massimo, Babudieri, Sergio, D’Arminio Monforte, Antonella, Andreoni, Massimo, Craxì, Antonio, Angelico, Mario, Pasquazzi, Caterina, Taliani, Gloria, Guedj, Jeremie, Perno, Carlo Federico, Ceccherini-Silberstein, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436665/
https://www.ncbi.nlm.nih.gov/pubmed/28545127
http://dx.doi.org/10.1371/journal.pone.0177352

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