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Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease

Increased intracellular cyclic AMP (cAMP) in renal tubular epithelia accelerates the progression of polycystic kidney disease (PKD). Thus, decreasing cAMP levels by an adenylyl cyclase inhibitory G protein activator is considered to be an effective approach in ameliorating PKD. In fact, pasireotide...

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Detalles Bibliográficos
Autores principales:	Kugita, Masanori, Nishii, Kazuhiro, Yamaguchi, Tamio, Suzuki, Atsushi, Yuzawa, Yukio, Horie, Shigeo, Higashihara, Eiji, Nagao, Shizuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436842/ https://www.ncbi.nlm.nih.gov/pubmed/28542433 http://dx.doi.org/10.1371/journal.pone.0177934

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