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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ligands of the epidermal growth factor recepto...

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Detalles Bibliográficos
Autores principales:	Grieve, Adam Graham, Xu, Hongmei, Künzel, Ulrike, Bambrough, Paul, Sieber, Boris, Freeman, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436907/ https://www.ncbi.nlm.nih.gov/pubmed/28432785 http://dx.doi.org/10.7554/eLife.23968

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