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A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity
In obesity, white adipose tissue (AT) inflammation is associated with reduced beige adipogenesis, a thermogenic and energy-dissipating function mediated by uncoupling protein-1 (UCP1)-expressing beige adipocytes. Here, we dissected an inflammation-driven inhibitory mechanism of beige adipogenesis in...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436941/ https://www.ncbi.nlm.nih.gov/pubmed/28414311 http://dx.doi.org/10.1038/ni.3728 |
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| author | Chung, Kyoung-Jin Chatzigeorgiou, Antonios Economopoulou, Matina Garcia-Martin, Ruben Alexaki, Vasileia I. Mitroulis, Ioannis Nati, Marina Gebler, Janine Ziemssen, Tjalf Goelz, Susan E. Phieler, Julia Lim, Jong-Hyung Karalis, Katia P. Papayannopoulou, Thalia Bluher, Matthias Hajishengallis, George Chavakis, Triantafyllos |
| author_facet | Chung, Kyoung-Jin Chatzigeorgiou, Antonios Economopoulou, Matina Garcia-Martin, Ruben Alexaki, Vasileia I. Mitroulis, Ioannis Nati, Marina Gebler, Janine Ziemssen, Tjalf Goelz, Susan E. Phieler, Julia Lim, Jong-Hyung Karalis, Katia P. Papayannopoulou, Thalia Bluher, Matthias Hajishengallis, George Chavakis, Triantafyllos |
| author_sort | Chung, Kyoung-Jin |
| collection | PubMed |
| description | In obesity, white adipose tissue (AT) inflammation is associated with reduced beige adipogenesis, a thermogenic and energy-dissipating function mediated by uncoupling protein-1 (UCP1)-expressing beige adipocytes. Here, we dissected an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated, respectively, by α(4) integrin and its counter-receptor VCAM-1, the expression of which was upregulated in obesity. This adhesive interaction reciprocally and concomitantly modulated inflammatory activation in macrophages and Erk-dependent downregulation of UCP1 in adipocytes. Genetic or pharmacologic inactivation of α(4) integrin in mice resulted in elevated UCP1 expression and beige adipogenesis of the subcutaneous AT in obesity. Our findings, established in both mouse and human systems, reveal a self-sustained cycle of inflammation-driven impairment of beige adipogenesis in obesity. |
| format | Online Article Text |
| id | pubmed-5436941 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54369412017-10-17 A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity Chung, Kyoung-Jin Chatzigeorgiou, Antonios Economopoulou, Matina Garcia-Martin, Ruben Alexaki, Vasileia I. Mitroulis, Ioannis Nati, Marina Gebler, Janine Ziemssen, Tjalf Goelz, Susan E. Phieler, Julia Lim, Jong-Hyung Karalis, Katia P. Papayannopoulou, Thalia Bluher, Matthias Hajishengallis, George Chavakis, Triantafyllos Nat Immunol Article In obesity, white adipose tissue (AT) inflammation is associated with reduced beige adipogenesis, a thermogenic and energy-dissipating function mediated by uncoupling protein-1 (UCP1)-expressing beige adipocytes. Here, we dissected an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated, respectively, by α(4) integrin and its counter-receptor VCAM-1, the expression of which was upregulated in obesity. This adhesive interaction reciprocally and concomitantly modulated inflammatory activation in macrophages and Erk-dependent downregulation of UCP1 in adipocytes. Genetic or pharmacologic inactivation of α(4) integrin in mice resulted in elevated UCP1 expression and beige adipogenesis of the subcutaneous AT in obesity. Our findings, established in both mouse and human systems, reveal a self-sustained cycle of inflammation-driven impairment of beige adipogenesis in obesity. 2017-04-17 2017-06 /pmc/articles/PMC5436941/ /pubmed/28414311 http://dx.doi.org/10.1038/ni.3728 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Chung, Kyoung-Jin Chatzigeorgiou, Antonios Economopoulou, Matina Garcia-Martin, Ruben Alexaki, Vasileia I. Mitroulis, Ioannis Nati, Marina Gebler, Janine Ziemssen, Tjalf Goelz, Susan E. Phieler, Julia Lim, Jong-Hyung Karalis, Katia P. Papayannopoulou, Thalia Bluher, Matthias Hajishengallis, George Chavakis, Triantafyllos A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| title | A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| title_full | A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| title_fullStr | A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| title_full_unstemmed | A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| title_short | A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| title_sort | self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436941/ https://www.ncbi.nlm.nih.gov/pubmed/28414311 http://dx.doi.org/10.1038/ni.3728 |
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