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First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437019/ https://www.ncbi.nlm.nih.gov/pubmed/28522868 http://dx.doi.org/10.1038/s41598-017-02377-w |
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author | Kishimoto, Aya Kataoka, Jun Taya, Takanori Tagawa, Leo Mochizuki, Saku Ohsuka, Shinji Nagao, Yuto Kurita, Keisuke Yamaguchi, Mitsutaka Kawachi, Naoki Matsunaga, Keiko Ikeda, Hayato Shimosegawa, Eku Hatazawa, Jun |
author_facet | Kishimoto, Aya Kataoka, Jun Taya, Takanori Tagawa, Leo Mochizuki, Saku Ohsuka, Shinji Nagao, Yuto Kurita, Keisuke Yamaguchi, Mitsutaka Kawachi, Naoki Matsunaga, Keiko Ikeda, Hayato Shimosegawa, Eku Hatazawa, Jun |
author_sort | Kishimoto, Aya |
collection | PubMed |
description | In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd(3)Al(2)Ga(3)O(12) scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that (131)I, (85)Sr, and (65)Zn can be new tracers that concentrate in each target organ. |
format | Online Article Text |
id | pubmed-5437019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54370192017-05-19 First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera Kishimoto, Aya Kataoka, Jun Taya, Takanori Tagawa, Leo Mochizuki, Saku Ohsuka, Shinji Nagao, Yuto Kurita, Keisuke Yamaguchi, Mitsutaka Kawachi, Naoki Matsunaga, Keiko Ikeda, Hayato Shimosegawa, Eku Hatazawa, Jun Sci Rep Article In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd(3)Al(2)Ga(3)O(12) scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that (131)I, (85)Sr, and (65)Zn can be new tracers that concentrate in each target organ. Nature Publishing Group UK 2017-05-18 /pmc/articles/PMC5437019/ /pubmed/28522868 http://dx.doi.org/10.1038/s41598-017-02377-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kishimoto, Aya Kataoka, Jun Taya, Takanori Tagawa, Leo Mochizuki, Saku Ohsuka, Shinji Nagao, Yuto Kurita, Keisuke Yamaguchi, Mitsutaka Kawachi, Naoki Matsunaga, Keiko Ikeda, Hayato Shimosegawa, Eku Hatazawa, Jun First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera |
title | First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera |
title_full | First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera |
title_fullStr | First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera |
title_full_unstemmed | First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera |
title_short | First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera |
title_sort | first demonstration of multi-color 3-d in vivo imaging using ultra-compact compton camera |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437019/ https://www.ncbi.nlm.nih.gov/pubmed/28522868 http://dx.doi.org/10.1038/s41598-017-02377-w |
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