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Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between adrenal...

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Autores principales: da Silveira Cruz-Machado, Sanseray, Tamura, Eduardo K., Carvalho-Sousa, Claudia E., Rocha, Vanderlei Amadeu, Pinato, Luciana, Fernandes, Pedro A. C., Markus, Regina P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437068/
https://www.ncbi.nlm.nih.gov/pubmed/28522814
http://dx.doi.org/10.1038/s41598-017-02286-y
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author da Silveira Cruz-Machado, Sanseray
Tamura, Eduardo K.
Carvalho-Sousa, Claudia E.
Rocha, Vanderlei Amadeu
Pinato, Luciana
Fernandes, Pedro A. C.
Markus, Regina P.
author_facet da Silveira Cruz-Machado, Sanseray
Tamura, Eduardo K.
Carvalho-Sousa, Claudia E.
Rocha, Vanderlei Amadeu
Pinato, Luciana
Fernandes, Pedro A. C.
Markus, Regina P.
author_sort da Silveira Cruz-Machado, Sanseray
collection PubMed
description Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between adrenal and pineal glands under inflammatory conditions indicates that corticosterone potentiates nocturnal melatonin synthesis by reducing the activity of NFκB. This transcription factor, which modulates the expression of a key enzyme in melatonin synthesis, is sharply reduced at the entrance of darkness in the rat pineal gland. In this study, we established the basis for understanding the crosstalk between adrenal and pineal glands in physiological conditions. Here we show that the expression of 70 out of 84 genes implied in defense responses exhibit a sharp reduction exactly at the entrance of darkness. Mifepristone impair the changes of 13 out of 84 genes, suggesting that the rhythm of corticosterone modulates pineal phenotype, as mifepristone also reduces the expression of Aanat and the nocturnal synthesis of melatonin. Therefore, darkness-induced synthesis of the pineal hormone, besides being controlled by the central clock located in the hypothalamus, is also influencedby glucocorticoids through the regulation of NFκB transcriptional program.
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spelling pubmed-54370682017-05-19 Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program da Silveira Cruz-Machado, Sanseray Tamura, Eduardo K. Carvalho-Sousa, Claudia E. Rocha, Vanderlei Amadeu Pinato, Luciana Fernandes, Pedro A. C. Markus, Regina P. Sci Rep Article Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between adrenal and pineal glands under inflammatory conditions indicates that corticosterone potentiates nocturnal melatonin synthesis by reducing the activity of NFκB. This transcription factor, which modulates the expression of a key enzyme in melatonin synthesis, is sharply reduced at the entrance of darkness in the rat pineal gland. In this study, we established the basis for understanding the crosstalk between adrenal and pineal glands in physiological conditions. Here we show that the expression of 70 out of 84 genes implied in defense responses exhibit a sharp reduction exactly at the entrance of darkness. Mifepristone impair the changes of 13 out of 84 genes, suggesting that the rhythm of corticosterone modulates pineal phenotype, as mifepristone also reduces the expression of Aanat and the nocturnal synthesis of melatonin. Therefore, darkness-induced synthesis of the pineal hormone, besides being controlled by the central clock located in the hypothalamus, is also influencedby glucocorticoids through the regulation of NFκB transcriptional program. Nature Publishing Group UK 2017-05-18 /pmc/articles/PMC5437068/ /pubmed/28522814 http://dx.doi.org/10.1038/s41598-017-02286-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
da Silveira Cruz-Machado, Sanseray
Tamura, Eduardo K.
Carvalho-Sousa, Claudia E.
Rocha, Vanderlei Amadeu
Pinato, Luciana
Fernandes, Pedro A. C.
Markus, Regina P.
Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_full Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_fullStr Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_full_unstemmed Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_short Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
title_sort daily corticosterone rhythm modulates pineal function through nfκb-related gene transcriptional program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437068/
https://www.ncbi.nlm.nih.gov/pubmed/28522814
http://dx.doi.org/10.1038/s41598-017-02286-y
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