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Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather than Collagen Density Weakens Cardiomyocyte Function
Cardiac fibrosis is one of the most devastating effects of cardiac disease. Current in vitro models of cardiac fibrosis do not sufficiently mimic the complex in vivo environment of the cardiomyocyte. We determined the local composition and mechanical properties of the myocardium in established mouse...
Autores principales: | van Spreeuwel, Ariane C.C., Bax, Noortje A.M., van Nierop, Bastiaan J., Aartsma-Rus, Annemieke, Goumans, Marie-José T.H., Bouten, Carlijn V.C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437129/ https://www.ncbi.nlm.nih.gov/pubmed/28281243 http://dx.doi.org/10.1007/s12265-017-9737-1 |
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