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Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity
Metformin is the first-line drug in the treatment of type 2 diabetes. In addition to its hypoglycemic effect, metformin has an anti-inflammatory function, but the precise mechanism promoting this activity remains unclear. High mobility group box 1 (HMGB1) is an alarmin that is released from necrotic...
Autores principales: | Horiuchi, Takahiro, Sakata, Natsumi, Narumi, Yoshihiro, Kimura, Tomohiro, Hayashi, Takashi, Nagano, Keisuke, Liu, Keyue, Nishibori, Masahiro, Tsukita, Sohei, Yamada, Tetsuya, Katagiri, Hideki, Shirakawa, Ryutaro, Horiuchi, Hisanori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437248/ https://www.ncbi.nlm.nih.gov/pubmed/28373282 http://dx.doi.org/10.1074/jbc.M116.769380 |
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