Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for N...

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Detalles Bibliográficos
Autores principales: Bednash, Joseph S., Weathington, Nathaniel, Londino, James, Rojas, Mauricio, Gulick, Dexter L., Fort, Robert, Han, SeungHye, McKelvey, Alison C., Chen, Bill B., Mallampalli, Rama K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437278/
https://www.ncbi.nlm.nih.gov/pubmed/28492230
http://dx.doi.org/10.1038/ncomms15203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437278/
https://www.ncbi.nlm.nih.gov/pubmed/28492230
http://dx.doi.org/10.1038/ncomms15203

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