Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation

AIMS: The type 2 diabetic heart oxidizes more fat and less glucose, which can impair metabolic flexibility and function. Increased sarcolemmal fatty acid translocase (FAT/CD36) imports more fatty acid into the diabetic myocardium, feeding increased fatty acid oxidation and elevated lipid deposition....

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Detalles Bibliográficos
Autores principales: Mansor, Latt S., Sousa Fialho, Maria da Luz, Yea, Georgina, Coumans, Will A., West, James A., Kerr, Matthew, Carr, Carolyn A., Luiken, Joost J.F.P., Glatz, Jan F.C., Evans, Rhys D., Griffin, Julian L., Tyler, Damian J., Clarke, Kieran, Heather, Lisa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437367/
https://www.ncbi.nlm.nih.gov/pubmed/28419197
http://dx.doi.org/10.1093/cvr/cvx045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437367/
https://www.ncbi.nlm.nih.gov/pubmed/28419197
http://dx.doi.org/10.1093/cvr/cvx045

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