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T-tubule remodelling disturbs localized β(2)-adrenergic signalling in rat ventricular myocytes during the progression of heart failure

AIMS: Cardiomyocyte β(2)-adrenergic receptor (β(2)AR) cyclic adenosine monophosphate (cAMP) signalling is regulated by the receptors’ subcellular location within transverse tubules (T-tubules), via interaction with structural and regulatory proteins, which form a signalosome. In chronic heart failur...

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Detalles Bibliográficos
Autores principales:	Schobesberger, Sophie, Wright, Peter, Tokar, Sergiy, Bhargava, Anamika, Mansfield, Catherine, Glukhov, Alexey V., Poulet, Claire, Buzuk, Andrey, Monszpart, Aron, Sikkel, Markus, Harding, Sian E., Nikolaev, Viacheslav O., Lyon, Alexander R., Gorelik, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437368/ https://www.ncbi.nlm.nih.gov/pubmed/28505272 http://dx.doi.org/10.1093/cvr/cvx074

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