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WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells

BACKGROUND: Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A affects...

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Detalles Bibliográficos
Autores principales: Skaria, Tom, Bachli, Esther, Schoedon, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437570/
https://www.ncbi.nlm.nih.gov/pubmed/28529460
http://dx.doi.org/10.1186/s12950-017-0157-4