Control of gene expression through the nonsense-mediated RNA decay pathway

Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents translation of mutant mRNAs harboring premature termination codons (PTCs) by targeting them for...

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Detalles Bibliográficos
Autores principales: Nickless, Andrew, Bailis, Julie M., You, Zhongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437625/
https://www.ncbi.nlm.nih.gov/pubmed/28533900
http://dx.doi.org/10.1186/s13578-017-0153-7
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author Nickless, Andrew
Bailis, Julie M.
You, Zhongsheng
author_facet Nickless, Andrew
Bailis, Julie M.
You, Zhongsheng
author_sort Nickless, Andrew
collection PubMed
description Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents translation of mutant mRNAs harboring premature termination codons (PTCs) by targeting them for degradation. However, recent studies have shown that NMD has a much broader role in gene expression by regulating the stability of many normal transcripts. In this review, we discuss the function of NMD in normal physiological processes, its dynamic regulation by developmental and environmental cues, and its association with human disease.
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spelling pubmed-54376252017-05-22 Control of gene expression through the nonsense-mediated RNA decay pathway Nickless, Andrew Bailis, Julie M. You, Zhongsheng Cell Biosci Review Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical function, NMD prevents translation of mutant mRNAs harboring premature termination codons (PTCs) by targeting them for degradation. However, recent studies have shown that NMD has a much broader role in gene expression by regulating the stability of many normal transcripts. In this review, we discuss the function of NMD in normal physiological processes, its dynamic regulation by developmental and environmental cues, and its association with human disease. BioMed Central 2017-05-19 /pmc/articles/PMC5437625/ /pubmed/28533900 http://dx.doi.org/10.1186/s13578-017-0153-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Nickless, Andrew
Bailis, Julie M.
You, Zhongsheng
Control of gene expression through the nonsense-mediated RNA decay pathway
title Control of gene expression through the nonsense-mediated RNA decay pathway
title_full Control of gene expression through the nonsense-mediated RNA decay pathway
title_fullStr Control of gene expression through the nonsense-mediated RNA decay pathway
title_full_unstemmed Control of gene expression through the nonsense-mediated RNA decay pathway
title_short Control of gene expression through the nonsense-mediated RNA decay pathway
title_sort control of gene expression through the nonsense-mediated rna decay pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437625/
https://www.ncbi.nlm.nih.gov/pubmed/28533900
http://dx.doi.org/10.1186/s13578-017-0153-7
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