Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication

In contrast to most DNA viruses, poxviruses replicate their genomes in the cytoplasm without host involvement. We find that vaccinia virus induces cytoplasmic activation of ATR early during infection, before genome uncoating, which is unexpected because ATR plays a fundamental nuclear role in mainta...

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Detalles Bibliográficos
Autores principales: Postigo, Antonio, Ramsden, Amy E., Howell, Michael, Way, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437729/
https://www.ncbi.nlm.nih.gov/pubmed/28467896
http://dx.doi.org/10.1016/j.celrep.2017.04.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437729/
https://www.ncbi.nlm.nih.gov/pubmed/28467896
http://dx.doi.org/10.1016/j.celrep.2017.04.025

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