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Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication
In contrast to most DNA viruses, poxviruses replicate their genomes in the cytoplasm without host involvement. We find that vaccinia virus induces cytoplasmic activation of ATR early during infection, before genome uncoating, which is unexpected because ATR plays a fundamental nuclear role in mainta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437729/ https://www.ncbi.nlm.nih.gov/pubmed/28467896 http://dx.doi.org/10.1016/j.celrep.2017.04.025 |