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The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case
Recent literature data have given emphasis to the relationship between gastrointestinal (GI) disorders and neurologic diseases, underlying a new pathogenic pathway: The so-called “gut–brain axis.” Herein, authors report a case of a 10-month-old male infant, admitted for drug-resistant epilepsy, asso...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437772/ https://www.ncbi.nlm.nih.gov/pubmed/28553399 http://dx.doi.org/10.4103/jpn.JPN_190_16 |
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author | Falsaperla, Raffaele Romano, Catia Pavone, Piero Vitaliti, Giovanna Yuan, Qian Motamed-Gorji, Nazgole Lubrano, Riccardo |
author_facet | Falsaperla, Raffaele Romano, Catia Pavone, Piero Vitaliti, Giovanna Yuan, Qian Motamed-Gorji, Nazgole Lubrano, Riccardo |
author_sort | Falsaperla, Raffaele |
collection | PubMed |
description | Recent literature data have given emphasis to the relationship between gastrointestinal (GI) disorders and neurologic diseases, underlying a new pathogenic pathway: The so-called “gut–brain axis.” Herein, authors report a case of a 10-month-old male infant, admitted for drug-resistant epilepsy, associated with irritable behavior and GI discomfort, secondary to cow's milk protein allergy. Seizures were described by parents as upward eye movements that were mostly deviated to the right and were associated with slight extension of his neck. They were infrequent at first, but had increased gradually during the course of 3 days (up to 15–20 times/day). No anticonvulsant therapy was effective. Only a cow's milk protein-free diet, accidentally started during a gastroenteritis episode, was effective in stopping seizures. Our case underlines the peculiar vulnerability of the blood–brain barrier under 1 year of age, for which children of this age group experience neurologic manifestations during episodes of systemic inflammation. |
format | Online Article Text |
id | pubmed-5437772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54377722017-05-26 The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case Falsaperla, Raffaele Romano, Catia Pavone, Piero Vitaliti, Giovanna Yuan, Qian Motamed-Gorji, Nazgole Lubrano, Riccardo J Pediatr Neurosci Case Report Recent literature data have given emphasis to the relationship between gastrointestinal (GI) disorders and neurologic diseases, underlying a new pathogenic pathway: The so-called “gut–brain axis.” Herein, authors report a case of a 10-month-old male infant, admitted for drug-resistant epilepsy, associated with irritable behavior and GI discomfort, secondary to cow's milk protein allergy. Seizures were described by parents as upward eye movements that were mostly deviated to the right and were associated with slight extension of his neck. They were infrequent at first, but had increased gradually during the course of 3 days (up to 15–20 times/day). No anticonvulsant therapy was effective. Only a cow's milk protein-free diet, accidentally started during a gastroenteritis episode, was effective in stopping seizures. Our case underlines the peculiar vulnerability of the blood–brain barrier under 1 year of age, for which children of this age group experience neurologic manifestations during episodes of systemic inflammation. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5437772/ /pubmed/28553399 http://dx.doi.org/10.4103/jpn.JPN_190_16 Text en Copyright: © 2017 Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Falsaperla, Raffaele Romano, Catia Pavone, Piero Vitaliti, Giovanna Yuan, Qian Motamed-Gorji, Nazgole Lubrano, Riccardo The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case |
title | The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case |
title_full | The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case |
title_fullStr | The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case |
title_full_unstemmed | The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case |
title_short | The Gut–brain Axis: A New Pathogenic View of Neurologic Symptoms – Description of a Pediatric Case |
title_sort | gut–brain axis: a new pathogenic view of neurologic symptoms – description of a pediatric case |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437772/ https://www.ncbi.nlm.nih.gov/pubmed/28553399 http://dx.doi.org/10.4103/jpn.JPN_190_16 |
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