Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification

Craniospinal rachischisis is a rare and severe form of neural tube defects (NTDs), which is always fatal. It is characterized by anencephaly accompanied by a bony defect of the spine and exposure of neural tissue. We describe the two patients with ultrasonographic and magnetic resonance imaging appe...

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Autores principales: Jaganmohan, Deepasree, Subramaniam, Prema, Krishnan, Nagarajan, Mahajan, Preetam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437784/
https://www.ncbi.nlm.nih.gov/pubmed/28553376
http://dx.doi.org/10.4103/1817-1745.205632
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author Jaganmohan, Deepasree
Subramaniam, Prema
Krishnan, Nagarajan
Mahajan, Preetam
author_facet Jaganmohan, Deepasree
Subramaniam, Prema
Krishnan, Nagarajan
Mahajan, Preetam
author_sort Jaganmohan, Deepasree
collection PubMed
description Craniospinal rachischisis is a rare and severe form of neural tube defects (NTDs), which is always fatal. It is characterized by anencephaly accompanied by a bony defect of the spine and exposure of neural tissue. We describe the two patients with ultrasonographic and magnetic resonance imaging appearance of craniospinal rachischisis totalis, detected antenatally at 22 and 25 weeks of gestation, and confirmed after termination of pregnancy. The multifactorial etiology of NTDs, with specific reference to folate deficiency, is discussed with possible role of folate fortification in the Indian context.
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spelling pubmed-54377842017-05-26 Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification Jaganmohan, Deepasree Subramaniam, Prema Krishnan, Nagarajan Mahajan, Preetam J Pediatr Neurosci Case Report Craniospinal rachischisis is a rare and severe form of neural tube defects (NTDs), which is always fatal. It is characterized by anencephaly accompanied by a bony defect of the spine and exposure of neural tissue. We describe the two patients with ultrasonographic and magnetic resonance imaging appearance of craniospinal rachischisis totalis, detected antenatally at 22 and 25 weeks of gestation, and confirmed after termination of pregnancy. The multifactorial etiology of NTDs, with specific reference to folate deficiency, is discussed with possible role of folate fortification in the Indian context. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5437784/ /pubmed/28553376 http://dx.doi.org/10.4103/1817-1745.205632 Text en Copyright: © 2017 Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Jaganmohan, Deepasree
Subramaniam, Prema
Krishnan, Nagarajan
Mahajan, Preetam
Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification
title Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification
title_full Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification
title_fullStr Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification
title_full_unstemmed Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification
title_short Two Cases of Craniospinal Rachischisis Totalis: Role of Magnetic Resonance Imaging in Diagnosis and Review of Neural Tube Defects in the Indian Context with Implications for Folate Fortification
title_sort two cases of craniospinal rachischisis totalis: role of magnetic resonance imaging in diagnosis and review of neural tube defects in the indian context with implications for folate fortification
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437784/
https://www.ncbi.nlm.nih.gov/pubmed/28553376
http://dx.doi.org/10.4103/1817-1745.205632
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