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Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway
RNA polymerase II-interacting the Set2 methyltransferase co-transcriptionally methylates histone H3 at lysine 36 within the body of genes. This modification facilitates histone deacetylation by Rpd3S HDAC in 3′ transcribed regions to suppress cryptic initiation and slow elongation. Although this pat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437959/ https://www.ncbi.nlm.nih.gov/pubmed/28320505 http://dx.doi.org/10.5483/BMBRep.2017.50.4.049 |
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author | Lee, Bo Bae Kim, Ji Hyun Kim, TaeSoo |
author_facet | Lee, Bo Bae Kim, Ji Hyun Kim, TaeSoo |
author_sort | Lee, Bo Bae |
collection | PubMed |
description | RNA polymerase II-interacting the Set2 methyltransferase co-transcriptionally methylates histone H3 at lysine 36 within the body of genes. This modification facilitates histone deacetylation by Rpd3S HDAC in 3′ transcribed regions to suppress cryptic initiation and slow elongation. Although this pathway is important for global deacetylation, no strong effects have been seen on genome-wide transcription under optimized laboratory conditions. In contrast, this pathway slows the kinetics of mRNA induction when target genes are induced upon environmental changes. Interestingly, a majority of Set2-repressed genes are overlapped by a lncRNA transcription that targets H3K36 methylation and deacetylation by Rpd3S HDAC to mRNA promoters. Furthermore, this pathway delays the induction of many cryptic transcripts upon environmental changes. Therefore, the Set2-Rpd3S HDAC pathway functions to fine-tune expression dynamics of mRNAs and ncRNAs. |
format | Online Article Text |
id | pubmed-5437959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-54379592017-06-01 Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway Lee, Bo Bae Kim, Ji Hyun Kim, TaeSoo BMB Rep Perspective RNA polymerase II-interacting the Set2 methyltransferase co-transcriptionally methylates histone H3 at lysine 36 within the body of genes. This modification facilitates histone deacetylation by Rpd3S HDAC in 3′ transcribed regions to suppress cryptic initiation and slow elongation. Although this pathway is important for global deacetylation, no strong effects have been seen on genome-wide transcription under optimized laboratory conditions. In contrast, this pathway slows the kinetics of mRNA induction when target genes are induced upon environmental changes. Interestingly, a majority of Set2-repressed genes are overlapped by a lncRNA transcription that targets H3K36 methylation and deacetylation by Rpd3S HDAC to mRNA promoters. Furthermore, this pathway delays the induction of many cryptic transcripts upon environmental changes. Therefore, the Set2-Rpd3S HDAC pathway functions to fine-tune expression dynamics of mRNAs and ncRNAs. Korean Society for Biochemistry and Molecular Biology 2017-04 2017-04-30 /pmc/articles/PMC5437959/ /pubmed/28320505 http://dx.doi.org/10.5483/BMBRep.2017.50.4.049 Text en Copyright © 2017 by the The Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspective Lee, Bo Bae Kim, Ji Hyun Kim, TaeSoo Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway |
title | Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway |
title_full | Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway |
title_fullStr | Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway |
title_full_unstemmed | Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway |
title_short | Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway |
title_sort | fine-tuning of gene expression dynamics by the set2-rpd3s pathway |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437959/ https://www.ncbi.nlm.nih.gov/pubmed/28320505 http://dx.doi.org/10.5483/BMBRep.2017.50.4.049 |
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