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microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor

Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified...

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Detalles Bibliográficos
Autores principales: Lee, Heejin, Tak, Hyosun, Park, So Jung, Jo, Yoon Kyung, Cho, Dong Hyung, Lee, Eun Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437966/
https://www.ncbi.nlm.nih.gov/pubmed/28148392
http://dx.doi.org/10.5483/BMBRep.2017.50.4.006
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author Lee, Heejin
Tak, Hyosun
Park, So Jung
Jo, Yoon Kyung
Cho, Dong Hyung
Lee, Eun Kyung
author_facet Lee, Heejin
Tak, Hyosun
Park, So Jung
Jo, Yoon Kyung
Cho, Dong Hyung
Lee, Eun Kyung
author_sort Lee, Heejin
collection PubMed
description Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression.
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spelling pubmed-54379662017-06-01 microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor Lee, Heejin Tak, Hyosun Park, So Jung Jo, Yoon Kyung Cho, Dong Hyung Lee, Eun Kyung BMB Rep Articles Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression. Korean Society for Biochemistry and Molecular Biology 2017-04 2017-04-30 /pmc/articles/PMC5437966/ /pubmed/28148392 http://dx.doi.org/10.5483/BMBRep.2017.50.4.006 Text en Copyright © 2017 by the The Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Lee, Heejin
Tak, Hyosun
Park, So Jung
Jo, Yoon Kyung
Cho, Dong Hyung
Lee, Eun Kyung
microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
title microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
title_full microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
title_fullStr microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
title_full_unstemmed microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
title_short microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
title_sort microrna-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437966/
https://www.ncbi.nlm.nih.gov/pubmed/28148392
http://dx.doi.org/10.5483/BMBRep.2017.50.4.006
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