Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis

We present the case of a 43-year-old woman with a diagnosis of pulmonary alveolar proteinosis, on chronic treatment with sargramostim, a recombinant granulocyte-macrophage colony-stimulating factor, who presented with the nephrotic syndrome secondary to biopsy-proven membranous nephropathy. We discu...

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Detalles Bibliográficos
Autores principales: Sewaralthahab, Kamal, Rennke, Helmut, Sewaralthahab, Sarah, Madias, Nicolaos E., Jaber, Bertrand L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dustri-Verlag Dr. Karl Feistle 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437997/
https://www.ncbi.nlm.nih.gov/pubmed/29043131
http://dx.doi.org/10.5414/CNCS108420
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author Sewaralthahab, Kamal
Rennke, Helmut
Sewaralthahab, Sarah
Madias, Nicolaos E.
Jaber, Bertrand L.
author_facet Sewaralthahab, Kamal
Rennke, Helmut
Sewaralthahab, Sarah
Madias, Nicolaos E.
Jaber, Bertrand L.
author_sort Sewaralthahab, Kamal
collection PubMed
description We present the case of a 43-year-old woman with a diagnosis of pulmonary alveolar proteinosis, on chronic treatment with sargramostim, a recombinant granulocyte-macrophage colony-stimulating factor, who presented with the nephrotic syndrome secondary to biopsy-proven membranous nephropathy. We discuss potential underlying mechanisms, including speculated effects of sargramostim on mesangial cells and the kidney resident macrophages, and review the existing literature on the potential association between these two disorders.
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spelling pubmed-54379972017-10-17 Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis Sewaralthahab, Kamal Rennke, Helmut Sewaralthahab, Sarah Madias, Nicolaos E. Jaber, Bertrand L. Clin Nephrol Case Stud Case Report We present the case of a 43-year-old woman with a diagnosis of pulmonary alveolar proteinosis, on chronic treatment with sargramostim, a recombinant granulocyte-macrophage colony-stimulating factor, who presented with the nephrotic syndrome secondary to biopsy-proven membranous nephropathy. We discuss potential underlying mechanisms, including speculated effects of sargramostim on mesangial cells and the kidney resident macrophages, and review the existing literature on the potential association between these two disorders. Dustri-Verlag Dr. Karl Feistle 2014-12-15 /pmc/articles/PMC5437997/ /pubmed/29043131 http://dx.doi.org/10.5414/CNCS108420 Text en © Dustri-Verlag Dr. K. Feistle http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sewaralthahab, Kamal
Rennke, Helmut
Sewaralthahab, Sarah
Madias, Nicolaos E.
Jaber, Bertrand L.
Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
title Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
title_full Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
title_fullStr Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
title_full_unstemmed Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
title_short Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
title_sort potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437997/
https://www.ncbi.nlm.nih.gov/pubmed/29043131
http://dx.doi.org/10.5414/CNCS108420
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