Structural and functional insight into human O-GlcNAcase

O-GlcNAc hydrolase, OGA, removes O-linked N-acetylglucosamine (O-GlcNAc) from myriad nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments we determined the 3-D structure of human OGA, revealing an unusual helix exchanged dimer that lays a structural foundation for an impro...

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Detalles Bibliográficos
Autores principales: Roth, Christian, Chan, Sherry, Offen, Wendy A, Hemsworth, Glyn R, Willems, Lianne I, King, Dustin T, Varghese, Vimal, Britton, Robert, Vocadlo, David J, Davies, Gideon J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438047/
https://www.ncbi.nlm.nih.gov/pubmed/28346405
http://dx.doi.org/10.1038/nchembio.2358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438047/
https://www.ncbi.nlm.nih.gov/pubmed/28346405
http://dx.doi.org/10.1038/nchembio.2358

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