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Structural and functional insight into human O-GlcNAcase

O-GlcNAc hydrolase, OGA, removes O-linked N-acetylglucosamine (O-GlcNAc) from myriad nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments we determined the 3-D structure of human OGA, revealing an unusual helix exchanged dimer that lays a structural foundation for an impro...

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Detalles Bibliográficos
Autores principales:	Roth, Christian, Chan, Sherry, Offen, Wendy A, Hemsworth, Glyn R, Willems, Lianne I, King, Dustin T, Varghese, Vimal, Britton, Robert, Vocadlo, David J, Davies, Gideon J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438047/ https://www.ncbi.nlm.nih.gov/pubmed/28346405 http://dx.doi.org/10.1038/nchembio.2358

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