T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

T0001 is a recombinant human TNFR-Fc fusion protein mutant; it exhibits higher affinity to TNFα than etanercept and is now being tested in a Phase 1 study in China (ClinicalTrials.gov Identifier: NCT02481180). T0001 can inhibit the binding of soluble TNFα (sTNFα) or membrane-bound TNFα (mTNFα) to TN...

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Detalles Bibliográficos
Autores principales: Shen, Yijun, Li, Gang, Gu, Chunying, Chen, Ben, Chen, Aihua, Li, Hua, Gao, Bei, Liang, Chencai, Wu, Jingsong, Yang, Tong, Jin, Li, Su, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438113/
https://www.ncbi.nlm.nih.gov/pubmed/28542350
http://dx.doi.org/10.1371/journal.pone.0177891

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