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Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury

Traumatic brain injury (TBI) initiates a deleterious inflammatory response that exacerbates pathology and worsens outcome. This inflammatory response is partially mediated by a reduction in cAMP and a concomitant upregulation of cAMP-hydrolyzing phosphodiesterases (PDEs) acutely after TBI. The PDE4B...

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Detalles Bibliográficos
Autores principales:	Wilson, Nicole M., Gurney, Mark E., Dietrich, W. Dalton, Atkins, Coleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438188/ https://www.ncbi.nlm.nih.gov/pubmed/28542295 http://dx.doi.org/10.1371/journal.pone.0178013

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