SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion

The posttranslational modifiers SUMO and ubiquitin critically regulate the DNA damage response (DDR). Important crosstalk between these modifiers at DNA lesions is mediated by the SUMO-targeted ubiquitin ligase (STUbL), which ubiquitinates SUMO chains to generate SUMO-ubiquitin hybrids. These SUMO-u...

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Detalles Bibliográficos
Autores principales: Nie, Minghua, Moser, Bettina A., Nakamura, Toru M., Boddy, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438191/
https://www.ncbi.nlm.nih.gov/pubmed/28475613
http://dx.doi.org/10.1371/journal.pgen.1006776

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