Cargando…

Chronic pain induces generalized enhancement of aversion

A hallmark feature of chronic pain is its ability to impact other sensory and affective experiences. It is notably associated with hypersensitivity at the site of tissue injury. It is less clear, however, if chronic pain can also induce a generalized site-nonspecific enhancement in the aversive resp...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Qiaosheng, Manders, Toby, Tong, Ai Phuong, Yang, Runtao, Garg, Arpan, Martinez, Erik, Zhou, Haocheng, Dale, Jahrane, Goyal, Abhinav, Urien, Louise, Yang, Guang, Chen, Zhe, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438248/
https://www.ncbi.nlm.nih.gov/pubmed/28524819
http://dx.doi.org/10.7554/eLife.25302
Descripción
Sumario:A hallmark feature of chronic pain is its ability to impact other sensory and affective experiences. It is notably associated with hypersensitivity at the site of tissue injury. It is less clear, however, if chronic pain can also induce a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs. Here, we showed that chronic pain in one limb in rats increased the aversive response to acute pain stimuli in the opposite limb, as assessed by conditioned place aversion. Interestingly, neural activities in the anterior cingulate cortex (ACC) correlated with noxious intensities, and optogenetic modulation of ACC neurons showed bidirectional control of the aversive response to acute pain. Chronic pain, however, altered acute pain intensity representation in the ACC to increase the aversive response to noxious stimuli at anatomically unrelated sites. Thus, chronic pain can disrupt cortical circuitry to enhance the aversive experience in a generalized anatomically nonspecific manner. DOI: http://dx.doi.org/10.7554/eLife.25302.001