TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overex...

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Detalles Bibliográficos
Autores principales: Ku, Amy T, Shaver, Timothy M, Rao, Ajay S, Howard, Jeffrey M, Rodriguez, Christine N, Miao, Qi, Garcia, Gloria, Le, Diep, Yang, Diane, Borowiak, Malgorzata, Cohen, Daniel N, Chitsazzadeh, Vida, Diwan, Abdul H, Tsai, Kenneth Y, Nguyen, Hoang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438253/
https://www.ncbi.nlm.nih.gov/pubmed/28467300
http://dx.doi.org/10.7554/eLife.23242

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