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Health benefit of vegetable/fruit juice-based diet: Role of microbiome
The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-based diets are becoming popular. However, there is a lack of scientific evidence of their hea...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438379/ https://www.ncbi.nlm.nih.gov/pubmed/28526852 http://dx.doi.org/10.1038/s41598-017-02200-6 |
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author | Henning, Susanne M. Yang, Jieping Shao, Paul Lee, Ru-Po Huang, Jianjun Ly, Austin Hsu, Mark Lu, Qing-Yi Thames, Gail Heber, David Li, Zhaoping |
author_facet | Henning, Susanne M. Yang, Jieping Shao, Paul Lee, Ru-Po Huang, Jianjun Ly, Austin Hsu, Mark Lu, Qing-Yi Thames, Gail Heber, David Li, Zhaoping |
author_sort | Henning, Susanne M. |
collection | PubMed |
description | The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-based diets are becoming popular. However, there is a lack of scientific evidence of their health benefits. It was our hypothesis that changes in the intestinal microbiota induced by a juice-based diet play an important role in their health benefits. Twenty healthy adults consumed only vegetable/fruit juices for 3 days followed by 14 days of customary diet. On day 4 we observed a significant decrease in weight and body mass index (p = 2.0E(−05)), which was maintained until day 17 (p = 3.0E(−04)). On day 4 the proportion of the phylum Firmicutes and Proteobacteria in stool was significantly decreased and Bacteroidetes and Cyanobacteria was increased compared to baseline and was partially reversed on day 17. On day 4 plasma and urine nitric oxide was increased by 244 ± 89% and 450 ± 360%, respectively, and urinary lipid peroxidation marker malondialdehyde was decreased by 32 ± 21% compared to baseline. General well-being score was increased at the end of the study. In summary a 3-day juice-based diet altered the intestinal microbiota associated with weight loss, increase in the vasodilator NO, and decrease in lipid oxidation. |
format | Online Article Text |
id | pubmed-5438379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54383792017-05-22 Health benefit of vegetable/fruit juice-based diet: Role of microbiome Henning, Susanne M. Yang, Jieping Shao, Paul Lee, Ru-Po Huang, Jianjun Ly, Austin Hsu, Mark Lu, Qing-Yi Thames, Gail Heber, David Li, Zhaoping Sci Rep Article The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-based diets are becoming popular. However, there is a lack of scientific evidence of their health benefits. It was our hypothesis that changes in the intestinal microbiota induced by a juice-based diet play an important role in their health benefits. Twenty healthy adults consumed only vegetable/fruit juices for 3 days followed by 14 days of customary diet. On day 4 we observed a significant decrease in weight and body mass index (p = 2.0E(−05)), which was maintained until day 17 (p = 3.0E(−04)). On day 4 the proportion of the phylum Firmicutes and Proteobacteria in stool was significantly decreased and Bacteroidetes and Cyanobacteria was increased compared to baseline and was partially reversed on day 17. On day 4 plasma and urine nitric oxide was increased by 244 ± 89% and 450 ± 360%, respectively, and urinary lipid peroxidation marker malondialdehyde was decreased by 32 ± 21% compared to baseline. General well-being score was increased at the end of the study. In summary a 3-day juice-based diet altered the intestinal microbiota associated with weight loss, increase in the vasodilator NO, and decrease in lipid oxidation. Nature Publishing Group UK 2017-05-19 /pmc/articles/PMC5438379/ /pubmed/28526852 http://dx.doi.org/10.1038/s41598-017-02200-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Henning, Susanne M. Yang, Jieping Shao, Paul Lee, Ru-Po Huang, Jianjun Ly, Austin Hsu, Mark Lu, Qing-Yi Thames, Gail Heber, David Li, Zhaoping Health benefit of vegetable/fruit juice-based diet: Role of microbiome |
title | Health benefit of vegetable/fruit juice-based diet: Role of microbiome |
title_full | Health benefit of vegetable/fruit juice-based diet: Role of microbiome |
title_fullStr | Health benefit of vegetable/fruit juice-based diet: Role of microbiome |
title_full_unstemmed | Health benefit of vegetable/fruit juice-based diet: Role of microbiome |
title_short | Health benefit of vegetable/fruit juice-based diet: Role of microbiome |
title_sort | health benefit of vegetable/fruit juice-based diet: role of microbiome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438379/ https://www.ncbi.nlm.nih.gov/pubmed/28526852 http://dx.doi.org/10.1038/s41598-017-02200-6 |
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