Dynamic monitoring of G(i/o)-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors

Analysis of G-protein-coupled receptor (GPCR) signaling, in particular of the second messenger cAMP that is tightly controlled by G(s)- and G(i/o)-proteins, is a central issue in biomedical research. The classical biochemical method to monitor increases in intracellular cAMP concentrations consists...

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Detalles Bibliográficos
Autores principales: Storch, Ursula, Straub, Julie, Erdogmus, Serap, Gudermann, Thomas, Mederos y Schnitzler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Ion Channels, Receptors and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438440/
https://www.ncbi.nlm.nih.gov/pubmed/28386636
http://dx.doi.org/10.1007/s00424-017-1975-1

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